Background Behind Our Technology

The concept of optically controlling biological processes is based on the research of Professor Moritoshi Sato at the University of Tokyo. He had the idea to use the light found in bio-imaging technology to control biological processes. Building on this idea, he developed a foundational technology that enables precise, light-triggered gene manipulation. This technology enables the dynamic control of essential biological functions, such as metabolism, secretion, proliferation, and programmed cell apoptosis, in both cells and microorganisms.

Revolutionary Photo-switchable Proteins

Although we might want to use light to manipulate biological functions, we need a tool with which to do so. To meet this need, Professor Sato applied protein engineering to photoreceptor proteins. These photo-switchable proteins function much like a magnet. They dimerize—that is, two protein subunits bind together—when exposed to light and monomerize—the subunits separate—when the light is turned off.

Biomanufacturing, evolved through Light

What becomes possible when we control the genes of cells and microorganisms with light? The possibilities are endless and transcend the conventional boundaries of biomanufacturing. We are expanding this foundational technology to drive biomanufacturing innovation.